Characteristics of Lynch syndrome in 13 Hispanic Families
نویسندگان
چکیده
منابع مشابه
Characteristics of Lynch syndrome in 13 Hispanic Families
Background While the incidence of colorectal cancer is lower in Hispanics than in non-Hispanic Caucasians, it is the second most common cancer in this diverse ethnic population. Emerging data indicate hereditary colon cancer syndromes contribute to cancer burden regardless of race and ethnicity. These data derive from research and cohorts where Hispanics are underrepresented. Here we report on ...
متن کاملGenetic anticipation in Swedish Lynch syndrome families
Among hereditary colorectal cancer predisposing syndromes, Lynch syndrome (LS) caused by mutations in DNA mismatch repair genes MLH1, MSH2, MSH6 or PMS2 is the most common. Patients with LS have an increased risk of early onset colon and endometrial cancer, but also other tumors that generally have an earlier onset compared to the general population. However, age at first primary cancer varies ...
متن کاملMLH1 Ile219Val Polymorphism in Argentinean Families with Suspected Lynch Syndrome
1 Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway, 2 Unit of Muscle Biology, Lund Transgenic Core Facility/Reproductive Immunology, Department of Experimental Medical Science, Lund University, Lund, Sweden, 3 Institute of Basic Sciences and Experimental Medicine (ICBME), Instituto Universitario Hospital Italiano, Buenos Aires, Argentina, 4 Prog...
متن کاملMutation spectrum in South American Lynch syndrome families
BACKGROUND Genetic counselling and testing for Lynch syndrome have recently been introduced in several South American countries, though yet not available in the public health care system. METHODS We compiled data from publications and hereditary cancer registries to characterize the Lynch syndrome mutation spectrum in South America. In total, data from 267 families that fulfilled the Amsterda...
متن کامل[Lynch syndrome: selection of families by microsatellite instability and immunohistochemistry].
BACKGROUND Selection of patients with Lynch Syndrome (LS) for a genetic study involves the application of clinical criteria. To increase the rate of identification of mutations, the use of molecular studies as Microsatellite Instability (MSI) and Immunohistochemistry (IHC) in the tumor has been proposed. AIM To demonstrate the usefulness of MSI and IHC in the detection of mutations in patient...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hereditary Cancer in Clinical Practice
سال: 2010
ISSN: 1897-4287
DOI: 10.1186/1897-4287-8-s1-p19